CpcS-III subfamily


Classification proposed by Shen et al. (2008) and Schluchter et al. (2010). None of the strains possessing the cpcS-III gene, including all PEC-containing strains, contains a cpcU-like gene (see phyletic profiles). The X-ray structure of CpcS-III from Thermosynechococcus elongatus BP1 (Tll1699) is available (PDB: 3BDR) and was crystallized as a homodimer. CpcS-III was erroneously called "CpeS1" by Zhao et al. (2007a) and Tu et al. (2008).


Phyre2 found the following protein fold for this family:



  • Saunée et al., 2008. Biogenesis of phycobiliproteins: II. CpcS-I and CpcU comprise the heterodimeric bilin lyase that attaches phycocyanobilin to Cys-82 of beta-phycocyanin and Cys-81 of allophycocyanin subunits in Synechococcus sp. PCC 7002 J Biol Chem, 283, 7513-7522.
  • Schluchter et al., 2010. Phycobiliprotein Biosynthesis in Cyanobacteria: Structure and Function of Enzymes Involved in Post-translational Modification Adv Exp Med Biol, 675, 211-228.
  • Shen et al., 2008. Biogenesis of phycobiliproteins: I. cpcS-I and cpcU mutants of the cyanobacterium Synechococcus sp. PCC 7002 define a heterodimeric phycocyanobilin lyase specific for beta-phycocyanin and allophycocyanin subunits J Biol Chem, 283, 7503-7512.
  • Tu et al., 2008. Intermediate binding of phycocyanobilin to the lyase, CpeS1, and transfer to apoprotein Photosynth Res, 95, 163-168.
  • Zhao et al., 2007a. Phycobilin:cystein-84 biliprotein lyase, a near-universal lyase for cysteine-84-binding sites in cyanobacterial phycobiliproteins Proc Natl Acad Sci USA, 104, 14300-14305.
  • Zhao et al., 2006. Chromophore attachment to phycobiliprotein beta-subunits: phycocyanobilin:cysteine-beta84 phycobiliprotein lyase activity of CpeS-like protein from Anabaena sp. PCC7120 J Biol Chem, 281, 8573-8581.

Gene Locus tag Genbank Species Strain PBP in rods Pigment type Remark Length Last change
CpcS-III subfamily alr0617 NP_484661.1 Anabaena (Nostoc) sp. PCC7120 PC+PEC 188 09-26-2011
CpcS-III subfamily Ava_4549 YP_325042.1 Anabaena variabilis ATCC29413 (PCC7937) PC+PEC 188 09-27-2011
CpcS-III subfamily Aazo_1709 YP_003720981.1 Anabaena (Nostoc) azollae 0708 PC+PEC 191 09-26-2011
CpcS-III subfamily Cyan7425_2083 YP_002482807.1 Cyanothece sp. PCC7425 PC 1 188 09-26-2011
CpcS-III subfamily FJSC11DRAFT_1071 ZP_08984865.1 Fischerella sp. (Mastigocladus laminosus) JSC-11 PC+PEC 187 11-04-2011
CpcS-III subfamily MC7420_7485 ZP_05023633.1 Microcoleus chthonoplastes PCC7420 PC+PEC 186 09-26-2011
CpcS-III subfamily N9414_02356 ZP_01632464.1 Nodularia spumigena CCY9414 PC 1 188 09-26-2011
CpcS-III subfamily CYB_2841 YP_479027.1 Synechococcus sp. JA-2-3B'a(2-13) PC 1 190 09-26-2011
CpcS-III subfamily CYA_2807 YP_476172.1 Synechococcus sp. JA-3-3Ab PC 1 187 09-26-2011
CpcS-III subfamily tll1699 NP_682489.1 Thermosynechococcus elongatus BP-1 PC 1 3D structure available (pdb:3BDR). N-term shortened (4 aa removed) 178 08-29-2012
CpcS-III subfamily CRD_00076 ZP_06303581.1 Raphidiopsis brookii D9 PC 1 Contains a group II intron containing an orf (gi|282895443|ref|ZP_06303580.1|)
This sequence is the fusion of CRD_00076 and CRD_00074 (KHEGSTVLVTVPDLLKPGEGKLLRE added before CRD_00074)
197 11-02-2011
CpcS-III subfamily CRC_02172 ZP_06308247.1 Cylindrospermopsis raciborskii CS-505 PC 1 Fusion of CRC_02170 and CRC_02172. Contains a group II intron (same as D9 strain). KHEGSTVLVTVPDLLKPGEGKLLRE added before CRC_02172 197 12-02-2011
CpcS-III subfamily GEI7407_2263 YP_007109790.1 Geitlerinema sp. PCC7407 PC 186 06-20-2013
CpcS-III subfamily Cri9333_3248 YP_007143590.1 Crinalium epipsammum PCC9333 PC 186 06-20-2013
CpcS-III subfamily Glo7428_4424 YP_007130027.1 Gloeocapsa sp. PCC7428 PC 187 04-22-2013
CpcS-III subfamily Syn7509DRAFT_00025220 ZP_21040972.1 Synechocystis sp. PCC7509 PC 185 04-22-2013
CpcS-III subfamily Anacy_0109 YP_007154628.1 Anabaena cylindrica PCC7122 PC+PEC 190 04-23-2013
CpcS-III subfamily Cylst_0830 YP_007145836.1 Cylindrospermum stagnale PCC7417 PC+PEC 191 04-23-2013
CpcS-III subfamily Nos7524_3943 YP_007077313.1 Nostoc sp. PCC7524 PC+PEC 187 04-23-2013
CpcS-III subfamily Riv7116_2426 YP_007055488.1 Rivularia sp. PCC7116 PC+PEC 188 04-23-2013
CpcS-III subfamily Chro_1676 YP_007091064.1 Chroococcidiopsis thermalis PCC7203 PC+PEC 186 04-23-2013
CpcS-III subfamily Nos7107_3741 YP_007051452.1 Nostoc sp. PCC7107 PC+PEC 187 04-29-2013
CpcS-III subfamily Cal7507_3605 YP_007066831.1 Calothrix sp. PCC7507 PC+PEC 188 04-29-2013
CpcS-III subfamily Fis9431DRAFT_3727 Fischerella sp. PCC9431 PC+PEC 187 06-12-2013
CpcS-III subfamily FIS9605DRAFT_06979 Fischerella sp. PCC9605 PC+PEC 188 06-12-2013
CpcS-III subfamily FisPCC73103_3408 Fischerella muscicola PCC73103 (SAG 1427-1) PC+PEC 187 06-12-2013
CpcS-III subfamily Scytonema_PCC7110_joined_11887 Scytonema hofmanni PCC7110 PC+PEC 189 06-12-2013
CpcS-III subfamily PCC9339DRAFT_01730 Fischerella sp. PCC9339 PC+PEC 187 06-12-2013
CpcS-III subfamily Ana7108_2980 Anabaena sp. PCC7108 PC+PEC 191 06-12-2013
CpcS-III subfamily Chloroglopsis_PCC9212_joined_7598 Chlorogloeopsis sp. PCC9212 PC+PEC 189 06-12-2013
CpcS-III subfamily UYC_05286 Chlorogloeopsis fritschii PCC6912 PC+PEC 189 06-12-2013
CpcS-III subfamily FisPCC7414_4393 Fischerella muscicola PCC7414 PC+PEC 187 06-12-2013
CpcS-III subfamily Fischerella_sp._PCC7521_3615 Fischerella thermalis PCC7521 PC+PEC 187 06-12-2013
CpcS-III subfamily Syn6312_0613 YP_007060377.1 Synechococcus sp. PCC6312 PC 186 06-12-2013
CpcS-III subfamily Syn7502_02665 YP_007106758.1 Synechococcus sp. PCC7502 PC 172 06-20-2013
CpcS-III subfamily Mic7113_0798 YP_007120112.1 Microcoleus sp. PCC7113 PC+PEI 2 Found both CpcS-I and CpcS-III in this strain? 188 06-20-2013

Model strain Model strains, Marine strains

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