MpeV family


MpeV is present only in marine Synechococcus strains belonging to pigment type 3dA, one of the two kinds of type IV chromatic acclimaters. MpeV has been biochemically characterized as a PEB:Cys-50,61 β-PEI and β-PEII lyase-isomerase in Synechococcus strain RS9916 (Carrigee et et al. 2021). Of note, the Cys-50-61 β-PEI of another 3dA strain WH8020 binds a PEB and not a PUB (Ong & Glazer, 1991). This discrepancy has been associated with the occurrence of a histidine at position 141 of the PEI β-subunit from WH8020, instead of a leucine in its counterpart from RS9916: this histidine was found to prevent the isomerization activity of MpeV (Carrigee et al. 2022).


  • Carrigee et al., 2021. MpeV is a lyase isomerase that ligates a doubly linked phycourobilin on the β-subunit of phycoerythrin I and II in marine Synechococcus J Biol Chem, 296, 100031.
  • Carrigee et al., 2022. The phycoerythrobilin isomerization activity of MpeV in Synechococcus sp. WH8020 is prevented by the presence of a histidine at position 141 within its phycoerythrin-I β-subunit substrate Front Microbiol, 13, 893413.
  • Ong et al., 1991. Phycoerythrins of marine unicellular cyanobacteria. I. Bilin types and locations and energy transfer pathways in Synechococcus spp. phycoerythrins J Biol Chem, 266, 9515-9527.

Gene Locus tag Genbank Species Strain PBP in rods Pigment type Remark Length Last change
MpeV family sync_0497 YP_729724.1 Synechococcus sp. CC9311 PC+PEI+PEII 3dA/CA4-A 301 04-20-2023
MpeV family Syncc9902_1901 YP_377902.1 Synechococcus sp. CC9902 PC+PEI+PEII 3dA/CA4-A 293 04-20-2023
MpeV family BL107_08916 ZP_01469886.1 Synechococcus sp. BL107 PC+PEI+PEII 3dA/CA4-A 308 04-20-2023
MpeV family RS9916_40196 ZP_01473082.1 Synechococcus sp. RS9916 PC+PEI+PEII 3dA/CA4-A 297 04-20-2023
MpeV family SynRCC307_2056 YP_001228312.1 Synechococcus sp. RCC307 PC+PEI+PEII 3eA 304 04-20-2023
MpeV family SynW8020_mpeV AAA27339.1 Synechococcus sp. WH8020 PC+PEI+PEII 3dA/CA4-A 301 04-20-2023

Model strain Model strains, Marine strains

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