MpeU family


Present only in PEII-containing marine Synechococcus, except low-PUB (pigment type 3a) strains (Six et al., 2007; Mahmoud et al., 2017; Grébert et al. 2022). Interruption of mpeU caused a reduction in PUB content, impaired phycobilisome assembly and reduced growth rate more strongly in blue than green light (Mahmoud et al.2017). MpeU is therefore important for adaptation of Synechococcus spp. to blue light but the site of this probable lyase-isomerase specificity remains to be established.


  • Grébert et al., 2022. Diversity and evolution of pigment types in marine Synechococcus cyanobacteria Genome Biol Evol, 14, evac035.
  • Mahmoud et al., 2017. Adaptation to blue light in marine Synechococcus requires MpeU, an enzyme with similarity to phycoerythrobilin lyase isomerases Front Microbiol, 8, 243.
  • Six et al., 2007. Diversity and evolution of phycobilisomes in marine Synechococcus spp.: a comparative genomics study Genome Biol, 8, R259.

Gene Locus tag Genbank Species Strain PBP in rods Pigment type Remark Length Last change
MpeU family sync_0501 YP_729728.1 Synechococcus sp. CC9311 PC+PEI+PEII 3dA/CA4-A 291 10-25-2011
MpeU family Syncc9605_0432 YP_380763.1 Synechococcus sp. CC9605 PC+PEI+PEII 3c 299 10-25-2011
MpeU family SH8109_0074 ZP_05788568.1 Synechococcus sp. WH8109 PC+PEI+PEII 3bB 298 10-25-2011
MpeU family SYNW2011 NP_898102.1 Synechococcus sp. WH8102 PC+PEI+PEII 3c 301 10-25-2011
MpeU family Syncc9902_1896 YP_377897.1 Synechococcus sp. CC9902 PC+PEI+PEII 3dA/CA4-A 298 10-25-2011
MpeU family BL107_08941 ZP_01469891.1 Synechococcus sp. BL107 PC+PEI+PEII 3dA/CA4-A 298 10-25-2011
MpeU family RS9916_40221 ZP_01473087.1 Synechococcus sp. RS9916 PC+PEI+PEII 3dA/CA4-A 298 10-25-2011
MpeU family SynRCC307_2051 YP_001228307.1 Synechococcus sp. RCC307 PC+PEI+PEII 3eA 298 10-25-2011
MpeU family SynWH8020_mpeU AAA27335.1 Synechococcus sp. WH8020 PC+PEI+PEII 3dA/CA4-A 297 08-26-2012

Model strain Model strains, Marine strains

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