CpeF family


CpeF was biochemically characterized as the lyase that ligates the doubly linked PEB on Cys-48,59 of β-phycoerythrin in Fremyella diplosiphon (Kronfel et al. 2019). It is related to the Synechococcus-specific lyase-isomerases MpeU (Mahmoud et al. 2017) and MpeV (Carrigee et al. 2021) and the yet uncharacterized Prochlorococcus-specific lyase (or lyase-isomerase?) MpeX (Hess et al. 1999).


  • Carrigee et al., 2021. MpeV is a lyase isomerase that ligates a doubly linked phycourobilin on the β-subunit of phycoerythrin I and II in marine Synechococcus J Biol Chem, 296, 100031.
  • Hess et al., 1999. Phycoerythrins of the oxyphotobacterium Prochlorococcus marinus are associated to the thylakoid membrane and are encoded by a single large gene cluster Plant Molecular Biology, 40, 507-521.
  • Kronfel et al., 2019. CpeF is the bilin lyase that ligates the doubly linked phycoerythrobilin on β-phycoerythrin in the cyanobacterium Fremyella diplosiphon J Biol Chem.
  • Mahmoud et al., 2017. Adaptation to blue light in marine Synechococcus requires MpeU, an enzyme with similarity to phycoerythrobilin lyase isomerases Front Microbiol, 8, 243.

Gene Locus tag Genbank Species Strain PBP in rods Pigment type Remark Length Last change
CpeF family SynWH7803_0489 YP_001224212.1 Synechococcus sp. WH7803 PC+PEI+PEII 3a 298 10-25-2011
CpeF family WH7805_06701 ZP_01123340.1 Synechococcus sp. WH7805 PC+PEI 2 298 10-25-2011
CpeF family SCB02_010100004358 ZP_07970141.1 Synechococcus sp. CB0205 PC+PEI 2 MLFPLLV not present in genbank 305 11-04-2011
CpeF family S7335_3548 ZP_05037110.1 Synechococcus sp. PCC7335 PC+PEI CA3 296 10-25-2011
CpeF family Syn8016DRAFT_2751 ZP_08957404.1 Synechococcus sp. WH8016 PC+PEI+PEII 3aA 308 11-04-2011
CpeF family CwatDRAFT_0409 ZP_00518851.1 Crocosphaera watsonii WH8501 PC+PEI 288 10-25-2011
CpeF family PCC7424_5719 YP_002381014.1 Cyanothece sp. PCC7424 PC+PEI 2 299 10-25-2011
CpeF family PCC8801_4511 YP_002364789.1 Cyanothece sp. PCC8801 PC+PEI 2 286 10-25-2011
CpeF family Cyan7822_4029 YP_003889229.1 Cyanothece sp. PCC7822 PC+PEI 2 294 10-25-2011
CpeF family gi|9622258|gb|AAF89697.1| AAF89697.1 Fremyella diplosiphon (Tolypothrix sp. / Calothrix sp.) Fd33 (UTEX481/PCC7601) PC+PEI CA3 303 10-25-2011
CpeF family gll1255 NP_924201.1 Gloeobacter violaceus PCC7421 PC+PEI 2 290 10-25-2011
CpeF family GL6909_3552 Gloeothece sp. PCC6909/1 PC+PEI 2 300 10-25-2011
CpeF family Npun_F3804 YP_001867131.1 Nostoc punctiforme ATCC29133 (PCC73102) PC+PEI 2 300 10-25-2011
CpeF family Tery_0978 YP_720832.1 Trichodesmium erythraeum IMS101 PC+PEI N-term shortened (24 aa removed) 310 08-30-2012
CpeF family Tery_0987 YP_720840.1 Trichodesmium erythraeum IMS101 PC+PEI Best BlastP hit on CpeF (but lower than Tery_0978) 285 08-30-2012
CpeF family LYNGBM3L_55090 ZP_08427735.1 Lyngbya majuscula 3L PC+PEI 2 289 10-28-2011
CpeF family S7335_4282 ZP_05037842.1 Synechococcus sp. PCC7335 PC+PEI CA3 Low blast and protomatch score. 332 01-02-2012
CpeF family CWATWH0003_5310t4 EHJ09925.1 Crocosphaera watsonii WH0003 PC+PEI incomplete n-term (start of contig) 262 02-22-2012
CpeF family MICAI_2830021 ZP_10228733.1 Microcystis sp. T1-4 PC+PEI 2 309 08-22-2012
CpeF family Ple7327_1461 YP_007080401.1 Pleurocapsa sp. PCC7327 PC+PEI 304 04-24-2013
CpeF family Mic7113_4746 YP_007123825.1 Microcoleus sp. PCC7113 PC+PEI 2 303 04-24-2013
CpeF family Osc7112_1017 YP_007113991.1 Oscillatoria nigro-viridis PCC7112 PC+PEI 2 293 04-24-2013
CpeF family Pse7367_3917 YP_007083570.1 Pseudanabaena sp. PCC7367 PC+PEI 311 04-24-2013
CpeF family GLO73106DRAFT_00012620 ZP_21051598.1 Gloeocapsa sp. PCC73106 PC+PEI 284 04-24-2013
CpeF family ZP_18907651 ZP_18907651.1 Leptolyngbya sp. PCC7375 PC+PEI 2 303 04-24-2013
CpeF family Lepto7376_4080 YP_007073044.1 Leptolyngbya sp. PCC7376 PC+PEI 300 04-24-2013
CpeF family Xen7305DRAFT_00032330 ZP_21054998.1 Xenococcus sp. PCC7305 PC+PEI 300 04-24-2013
CpeF family Cal6303_1005 YP_007136042.1 Calothrix sp. PCC6303 PC+PEI 2 302 04-29-2013
CpeF family Sta7437_3852 YP_007134302.1 Stanieria cyanosphaera PCC7437 PC+PEI 295 04-29-2013
CpeF family Cha6605_4057 YP_007098540.1 Chamaesiphon minutus PCC6605 PC+PEI 305 04-29-2013
CpeF family Cal6303_4952 YP_007139821.1 Calothrix sp. PCC6303 PC+PEI 2 299 04-29-2013

Model strain Model strains, Marine strains

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